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At the 2001 FASEB Conference, The Calpain Family in Health and
Disease, a discussion was held concerning calpain nomenclature. The proposed
changes are summarized below. You
may download a copy of these tables in pdf format. If you have comments or
suggestions on the nomenclature of the calpains, please fill out our survey
form.
Table 1. Mammalian calpain family
|
Calpain
protein #
|
Calpain
gene
|
Other
Names
|
EF-hand
|
Tissue
Type
|
Species
|
Chromo-some
#
|
Genebank
Accession #
|
|
Calpain
1
|
capn1
|
µ-Calpain,
CAPN1
|
+
|
Ubiquitous
|
Human
|
11q13
|
X04366
|
|
Mouse
|
19
|
NM_007600
|
|
Rat
|
NA
|
NM_019152
|
|
Calpain
2
|
capn2
|
m-Calpain,
CAPN2
|
+
|
Ubiquitous
|
Human
|
1q41
|
NM_001748
|
|
Mouse
|
NA
|
NM_009794
|
|
Rat
|
NA
|
NM_017116
|
|
Calpain
3
|
capn3
|
nCL-1,
p94,
(Lp82,
Lp85
Rt88)
|
+
|
Skeletal
muscle,
lens,
retina
|
Human
|
15q15.1
|
X85030
|
|
Mouse
|
2
|
NM_007601
AF091998
|
|
Rat
|
NA
|
NM_017117
U96367
|
|
Calpain 5
|
capn5
|
htra3
nCL-3
|
-
|
Ubiquitous
(High in colon, small intestine and testis)
|
Human
|
11q14
|
NM_004055
|
|
Mouse
|
7
|
NM_007602
|
|
Rat
|
NA
|
NA
|
|
Calpain
6
|
capn6
|
CAPNX,
Calpamodulin
|
-
|
Placenta?
|
Human
|
Xq28
|
NM_014289
|
|
Mouse
|
X
|
NM_007603
|
|
Rat
|
NA
|
AF067793
|
|
Calpain
7
|
capn7
|
palBH
|
-
|
Ubiquitous
|
Human
|
3p24-p25
|
AB028639
|
|
Mouse
|
NA
|
NM_009796
|
|
Rat
|
NA
|
NA
|
|
Calpain
8
|
capn8
|
nCL-2
|
+
|
Stomach
mucosa
|
Human
Mouse
Rat
|
1q41
NA
NA
|
AA_043093^
|
|
NA
|
|
D14479-D14480
|
|
Calpain
9
|
capn9
|
nCL-4
|
+
|
Digestive
track
|
Human
|
1q42
|
NM_006615
|
|
Mouse
|
NA
|
U89513
|
|
Rat
|
NA
|
U89514
|
|
Calpain
10
|
capn10
|
CAPN10,
CaPn8
|
-
|
Ubiquitous
|
Human
|
2q37.3
|
AF089088,
AF089090
-96
|
|
Mouse
|
NA
|
NM_011796
AF089089
|
|
Rat
|
NA
|
AF227909
|
|
Calpain
11
|
capn11
|
CAPN11
|
+
|
Testis
|
Human
|
6p12
|
AJ242832
|
|
Mouse
|
NA
|
NA
|
|
Rat
|
NA
|
NA
|
|
Calpain
12
|
capn12
|
CAPN12
|
+
|
Ubiquitous
(High
in hair follicle)
|
Human
|
NA
|
NA
|
|
Mouse
|
19q13
|
AJ289241
|
|
Rat
|
NA
|
NA
|
|
Calpain
13
|
capn13
|
CAPN13
|
+
|
Testis/Lung
|
Human
|
2p22.2-p22.3
|
(AC068689)
^
|
|
Calpain
14
|
capn14
|
CAPN14
|
_
|
Ubiquitous
|
Human
|
2p22.2-p22.3
|
(AC015980)
^
|
|
Calpain
15
|
capn15
|
Sol
H
|
-
|
Ubiquitous
|
Human
|
16p13.3
|
U85647
|
|
Mouse
|
17A3.3
|
NM015830
|
|
Rat
|
NA
|
NA
|
|
Calpain
Small Subunit 1
|
capn-s1
or
cpns1
|
CAPN4
|
+
|
Ubiquitous
|
Human
|
19q13.1
|
NM_001749
|
|
Mouse
|
NA
|
NM_009795
|
|
Rat
|
NA
|
RNU10861
|
|
Calpain
Small Subunit 2
|
capn-s2
or
cpns2
|
|
+
|
NA
|
Human
|
16
|
AC026802
|
|
Mouse
|
NA
|
AK009171
|
|
Rat
|
NA
|
NA
|
*Proposed
name
# Old name
^
Partial sequences only
NA = Not available
Note: There will be no calpain 4
µ-Calpain =protein
heterodimer of Calpain 1 and one small subunit
m-Calpain
=protein heterodimer of Calpain 2 protein and one small subunit
Table 2. Calpain family in Drosophila
Drosophila Calpain protein
|
gene
|
Other names
|
|
Calpain A
|
CalpA
|
Dm-Calpain A
|
|
Calpain B
|
CalpB
|
Dm-Calpain B
|
|
Calpain C
|
CalpC
|
CCG3692
|
|
Calpain D
|
CalpD
|
SOL
|
Table 3.Nematode C. elegans calpain
There are 12 putative calpains with 7 identified in C. elegans.
C. elegans Calpain protein
|
gene
|
Other names
|
|
Calpain 1
|
capn1
|
CE00518/ p71
|
|
Calpain 2
|
capn2
|
CE01070/ p92
|
|
Calpain 3
|
capn3
|
CE24374/ p72.8
|
|
Calpain 4
|
capn4
|
CE25258/ p76
|
|
Calpain 5
|
capn5
|
CE16260/ TRA-3
|
|
Calpain 6
|
capn6
|
CE25611/ p90
|
|
Calpain 7
|
capn7
|
CE25612/ p86
|
|
