Hun, L., Luckhart, S. and Riehle, M.A. Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides. Journal of insect physiology, p.103932 (2019).
Souvannaseng, L., Hun, L.V., Baker, H., Klyver, J.M., Wang, B., Pakpour, N., Bridgewater, J.M., Napoli, E., Giulivi, C., Riehle, M.A. and Luckhart, S. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS pathogens, 14(11), p.e1007418 (2018).
Ernst, K.C., Walker, K.R., Reyes-Castro, P., Joy, T.K., Castro-Luque, A.L., Diaz-Caravantes, R.E., Gameros, M., Haenchen, S., Hayden, M.H., Monaghan, A., Jeffrey-Guttierez, E., Carrière Y., and Riehle, M.A. Aedes aegypti (Diptera: Culicidae) Longevity and Differential Emergence of Dengue Fever in Two Cities in Sonora, Mexico. Journal of Medical Entomology, 54(1), pp.204-211. (2017)
Pietri J.E., Pietri E.J., Potts R., Riehle M.A. & Luckhart S. Plasmodium falciparum suppresses the host immune response by inducing the synthesis of insulin-like peptides (ILPs) in the mosquito Anopheles stephensi. Developmental & Comparative Immunology, 53(1), 134-144. (2015).
Arik A.J., Hun L.V., Quicke K., Piatt M., Ziegler R., Scaraffia P.Y., Badgandi H., Riehle M.A. Increased Akt signaling in the mosquito fat body increases adult survivorship. FASEB J. 29(4): 1404-1413. (2015)
Pakpour N., Riehle M.A., Luckhart S., Effects of ingested vertebrate-derived factors on insect immune responses. Current Opinion in Insect Science. 3:1-5 (2014)
Drexler AL., Pietri JE., Pakpour N., Hauck E., Wand B., Glennon EKK., Georgis M., Riehle MA., Luckhart S. Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. PLoS Pathog 10(6): e1004231. DOI: 10.1371/journal.ppat.1004231. (2014)
Hauck ES., Antonova-Koch Y., Drexler A., Pietri J., Pakpour N., Liu D., Blacutt J., Riehle MA., Luckhart S. Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes and Infection. doi: 10.1016/j.micinf.2013.05.006. (2013)
Luckhart S., Giulivi C., Drexler A.L., Antonova-Koch Y., Sakaguchi D., Napoli E., Wong S., Price M.S., Eigenheer R., Phinney B.S., Pakpour N., Pietri J.E., Cheung K., Georgis M., and Riehle M.A. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito most. PLoS Pathog 9(2): e1003180. doi:10.1371/journal.ppat.1003180. (2013)
Joy T.K., Jeffrey Gutierrez E.H., Ernst K., Walker K.R., Carriere Y., Torabi M., Riehle M.A. Aging field collected Aedes aegypti to determine their capacity for dengue transmission in the Southwestern United States. PLoS One 10.1371/journal.pone.0046946 (2012)
Pakpour N., Corby-Harris V. †, Green G., Smithers H., Cheung K., Riehle M.A., and Luckhart S. Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum. Infection and Immunity. 80(6):2141-9. (2012)
Antonova Y., Arik A.J., Moore W, Riehle M.A., and Brown M.R. Insulin-like peptides: Structure, signaling, and function. In Gilbert L.I. (Ed) Insect Endocrinology (pp. 63-92). Academic Press. (2012)
Marquez A.G., Pietri J.E., Smithers H.M., Nuss A., Antonova Y., Drexler A.L., Riehle M.A., Brown M.R., and Luckhart S.L. Insulin-like peptides in the mosquito Anopheles stephensi: identification and expression in response to diet and infection with Plasmodium falciparum. General and Comparative Endocrinology. 173(2). 303-12. (2011)
Corby-Harris V., Drexler A., Watkins de Jong L., Antonova Y., Pakpour N., Ziegler R., Ramberg F., Lewis E.E., Brown J.M, Luckhart S., and Riehle M.A. Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopeheles stephensi mosquitoes. PLoS Pathogens. 6(7). e1001003 (2010)
